Mesenchymal Stem Cell Therapy for COVID-19: Present or Future

“COVID-19” is the word that certainly isn’t forgotten by everybody who lives in the first half of the twenty-first century. COVID-19, as a pandemic, has led many researchers from different biomedical fields to find solutions or treatments to manage the pandemic. However, no standard treatment for this disease has been discovered to date. Probably, preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. Recently, MSCs according to their immunomodulatory and regenerative properties attract attention in clinical trials. After the intravenous transplantation of MSCs, a significant population of cells accumulates in the lung, which they alongside immunomodulatory effect could protect alveolar epithelial cells, reclaim the pulmonary microenvironment, prevent pulmonary fibrosis, and cure lung dysfunction. Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. In this study, we considered this new approach to improve patient’s immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment. However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing.

At the 2019 year’s end, numerous cases of severe respiratory infections were reported in Wuhan, China, and were initially thought to be a seasonal flu disease, given that some patients had a history of attending or working in the wholesale market for fish and seafood. The market was immediately shut down on January 1, and environmental sanitation and sanitation were fully implemented. A few days later, after rejecting the diagnosis of seasonal influenza, avian influenza, adenovirus, coronavirus, SARS, coronavirus, and other pathogens, on Jan. 1, the virus was declared a causative agent of the disease in four of the nine hospitalized patients: A new coronavirus that has a 5% genetic association with SARS and is a subset of Sarbecovirus []. Currently, the virus has been briefly named SARS-CoV-2 virus for further information and COVID-19, the name was given by the World Health Organization (WHO) to the SARS-CoV-2 virus-associated disease.

This disease has resulted in that clinicians and researchers from different branches of biomedicine were mobilized to find a solution or treatment for the management of this pandemic. According to a recent announcement of the International Society for Stem Cell Research (ISSCR), currently, there are no approved stem cell-based approaches for the prevention and treatment of COVID-19 infection. However, recently, mesenchymal stem cells (MSCs) have introduced one of the therapeutic approaches for using in the treatment of COVID-19 []. As we know, MSCs opposes viral infection due to the presence of specific cytokines improved qualities. These features are present in MSCs in the intrinsic niche before their separation process happens. Therefore, MSCs can be expected to survive even if they are transplanted into a patient with a confirmed COVID-19. Due to there is disagreement in MSCs therapy to treat COVID-19, we reviewed reported clinical trials and news to present helpful information to researchers and enthusiasts of the stem cell-based therapy field. In this study, we considered this proposed approach to improve patient’s immunological responses to COVID-19 using MSCs and discussed the aspects of this therapeutic approach.

“COVID-19” the word that certainly it isn’t forgotten by everybody who lived in the first half of the twenty-first century.


Immunomodulatory and anti-inflammatory properties of MSCs in the treatment of respiratory diseases were confirmed by 17 completed clinical studies, and also more than 70 trials are registered in this regard ( To date, 20 clinical trials have been registered in the Chinese clinical trial registry site ( In addition, 9 clinical trials have been registered in Umbilical cord, umbilical cord blood, Wharton’s jelly, menstrual blood, dental pulp, and the company produced-MSCs are the important MSC sources that will be used in these trials. However, the process of developing new therapeutic and bringing it to clinical application has important practical implications and not over for MSC therapy of COVID-19. However, the cost-effective and speed of therapeutic preparation are the capable discussed topic for MSC-based therapy for COVID-19, but certainly, the life of a human is more worthy and COVID-19 is so dangers. Therefore, the clinical use of MSCs therapy to treat COVID-19 is still some time away, but there are some promising reports to apply. Stem cell therapy and especially MSCs may possibly be is one of the most ideal therapeutics, or a combination of treatment to treat COVID-19 patients. However, scientists are trying incessantly to develop a vaccine for COVID-19, as well as therapeutics to treat this disease.


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